Description: Overview of clinical nephrotoxicity (W.M. Bennett). Functional anatomy of the kidney (J.M. Sands, J.W. Verlander). Functional anatomy of the mammalian urinary bladder (M.L. Zeidel). Renal tubular transport of organic anions and cations (W.H. Dantzler, S.H. Wright). Xenobiotic metabolism (E.A. Lock). Methods to evaluate renal function (L.B. Kinter, J.B. Tarloff). Acute renal failure (M. Brezis, D. Dinour). The tubulointerstitium as a target (J.R. Diamond, S.D. Ricardo). Adaptation in progression of renal injury (A. Fogo). Vasoactive substances as mediators of renal injury (K.F. Badr). The glomerulus: mechanisms of injury (G. Remuzzi, M. Abbate). The proximal tubule as a target (C.E. Ruegg). Biochemical mechanisms of proximal tubular cell death (R.G. Schnellmann, G.W. Miller). The renal medulla and distal nephron toxicity (P.H. Bach). Membrane fluidity and composition (B.A. Molitoris). Cell adhesion molecules in renal injury (M.S. Goligorsky, E. Noiri, J. Gailit, H.R. Brady, V. Romanov). Immune response of the kidney (G.C. Groggel). Carcinogenic response of the kidney (S.L. Eustis). Carcinogenic response of the bladder (T.V. Zenser, V.M. Lakshmi, B.B. Davis). Glutathione status and other antioxidant defence mechanisms (L.H. Lash). Molecular events in ischemic renal injury and repair (J.V. Bonventre, R. Witzgall). Gene expression following nephrotic exposure (R.L. Safirstein). In vitro toxicity systems (S.M. Ford). Nephrotoxicity of &bgr;-lactam antibiotics (B.M. Tune). Amphotericin B (R.A. Branch, J.F. Bernardo). Aminoglycosides nephrotoxicity (C. Cojocel). Antineoplastic agents (G.H.I. Wolfgang, M.E.I. Leibrandt). Radiocontrast agents (G.L. Bakris). Cyclosporine (J. Mason, L.C. Moore). Analgesics and nonsteroidal antiinflammatory drugs (J.B. Tarloff). Halogenated hydrocarbons (A.A. Elfarra). Bromobenzene nephrotoxicity: a model of metabolism-dependent toxicity (S.S. Lau, T.J. Monks). Renal toxicity of mercury (R.K. Zalups). Other metals (B.A. Fowler, K. S. Squibb). Succinimides (G.O. Rankin). Zu-globulin nephrotoxicity (L.D. Lehman-McKeeman).

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