Description: Chapter headings and selected papers: Plenary Papers.Computer application in bio-process engineering in Japan (T. Yoshida). Modeling, Simulation, Design and Optimization of Bioprocesses. Improving the estimation of parameters of penicillin fermentation models (M.T. Syddall et al.). Modeling and simulation of gas-liquid-liquid extractive cultivation processes - biodegradation of xenobiotics (K. Bagherpour et al.). Model discrimination and parameter identification by an experimental design strategy (R. Takors et al.). Robotics in Biotechnology. Automated synthesis apparatus for pharmaceuticals (T. Sugawara). Knowledge Engineering Approaches for Bioprocess Operation. Stress monitoring in recombinant fermentations for artificial neural network control (A.J. Austin et al.). Design of an expert system for selection of protein purification processes: comparison between different selection criteria (M.E. Lienqueo et al.). Computer Application in Metabolic Engineering. Optimization and control of metabolic systems (R. Heinrich). Instrumentation and Data Processing. On-line monitoring and optimal adaptive control of the fed-batch baker's yeast fermentation (J.E. Claes, J.F. Van Impe). Database mining tools for bioprocess analysis (R.T. Kamimura et al.). Cell Culture Engineering and Clinical Application. Modeling of multiple steady states in mammalian cells. A cybernetic approach (M.J. Guardia et al.). Cell therapy by using genetic engineered glomerular cells to remove immune complex deposited on kidney (P.C. Wang et al.). Application to Environmental Engineering. Process simulation of desulfurization from pyrite by thiobacillus ferrooxidans in a packed-bed medium-recirculating bioreactor under different recirculation rates (D-D. Xu et al.). Equilibrium model for an anaerobic fixed-film reactor (H. Chua). Author Index.

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