- ISBN10: 0125468202
Excitatory Amino Acids Clinical Results With Antagonists
- List Price: $280.00
- Binding: Hardcover
- Publisher: Academic Pr
- Publish date: 01/01/1997
The study of amino acids and their roles in central nervous system disorders is one of the fastest-moving and most important subjects in neurology today. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. It is a companion volume to Wheal and Thomson's thorough Excitatory Amino Acids, Second Edition (1995, Academic Press).
Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters.
-- Describes the development of NMDA (N-methyl-D-aspartate) and non-NMDA antagonists
-- Concentrates on the results of human testing of modulators of excitatory amino acid neurotransmitters
-- Coverage of the field of excitatory amino acids from synaptic function to pre-clinical and clinical pharmacology
-- Features reports of potential drugs in early and late clinical stages of development