Error title
Some error text about your books and stuff.
Close
Neurodegeneration and Neuroprotection in Parkinson's Disease cover
  • ISBN: 9780125254458
  • ISBN10: 0125254458

Neurodegeneration and Neuroprotection in Parkinson's Disease

by Peter Jenner

  • List Price: $130.00
  • Binding: Hardcover
  • Publisher: Academic Pr
  • Publish date: 04/01/1996
used Add to Cart $24.16
You save: 81%
Marketplace Item
new Add to Cart $57.55
You save: 56%
Marketplace Item
License: 30 days
Description
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by a relatively selective degeneration of dopaminergic neurons, a loss of striatal dopamine, and intracellular inclusions. Current treatment consists of a dopamine replacement strategy, primarily using the dopamine precursor levodopa. However the majority of patients experience intolerable drug-related side effects, an unacceptable level of disability, and an increased mortality rate. Accordingly, there has been intense interest in the development of a 'neuroprotective therapy' that can prevent neuronal degeneration and slow or stop disease progression. It is likely that a cascade of events involving free radicals and oxidative stress, mitochondrial dysfunction with a bioenergetic impairment, excitotoxicity, and a rise in intracytoplasmic free calcium with activation of biodestructive enzymes contributes to the neurodegenerative process. There is also interest in the role of apoptotic cell death in neurodegeneration and the possibility that some small molecules can provide neuroprotection or neuronal rescue by upregulating cellular defenses through the induction of translational changes and new protein synthesis. This is the first book to comprehensive review the factors implicated in the pathogenesis of cell death in PD. Each chapter of this book examines a different factor and considers the evidence supporting its participation in the neurodegenerative process and specific strategies based on this mechanism that might lead to neuroprotection.
Expand description
Seller Condition Comments Price  
stressfreesales

Location: Bay City, MI
Like New
Shipping Icon
LIKE NEW: Little to no shelf wear, no signs of use. Ships fast & secure, expedited available!
$24.16
booksdiscount11

Location: Sterling Hts, MI
Ask seller a question
New
New Book Original US edition, Ships with Emailed Tracking from USA. We Ship to PO BOX Address also.
$57.55
discount_scientific_books

Location: Sterling Heights, MI
New
New Book Original US edition, We Ship to PO BOX Address also.
$70.22
Basi6 International

Location: Irving, TX
New
New, US edition. Satisfaction guaranteed! !
$70.37