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  • ISBN: 9780123049902
  • ISBN10: 0123049903

Neuropeptide Y and Drug Development

by Stephen R. Bloom

  • List Price: $190.00
  • Binding: Hardcover
  • Publisher: Academic Pr
  • Publish date: 01/01/1997
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Description
Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, and has attracted much interest because of the large number of physiological effects attributed to it. The peptide is one of the most potent stimuli of food intake known, and is involved in the body energy balance. In addition, it acts as a vasoconstrictor several orders of magnitude more potent than noradrenaline. Neuropeptide Y and Drug Development links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance.The chapters are written by leaders in their respective fields from both academia and the pharmaceutical industry. Because NPY receptors are promising drug targets, a detailed description of the development of peptide and non-peptide receptor antagonists is included. This book is of interest to anyone working in the areas of hypertension, food intake, and sexual function, as well as those interest in the development of drugs as NPY targets.<BR>-- Provides a detailed description of the hypothalamic role of NPY and its relationship with eating disorders and diabetes<BR>-- Covers the sympathetic nervous system role of NPY and its involvement in cardiovascular disorders<BR>-- Describes characterized NPY receptor sub-types and their brain distribution, molecular biology, and pharmacology<BR>-- Includes data on several NPY receptors which have been cloned and shown to belong to the family of G-protein coupled receptors
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