This edition includes vital new information on cytokines and cytokine receptors, signal transduction, mechanisms of cellular adhesion, angiogenesis, and wound healing. The "Clinical Correlates" section features new chapters on autoantibodies, sepsis and septic shock, reperfusion injury, type 1 diabetes, inflammation and cancer, cancer immunology, and induction of inflammation by Helicobacter pylori. The section on therapeutic modulation of inflammation includes new chapters on complement inhibitors, cytokine inhibitors, agents targeting transcription factors, and emerging technologies for the discovery of small-molecule therapeutics. Other new chapters in this section cover second line antirheumatic drugs, tolerance to anti-inflammatory drugs, immunomodulation by intravenous gammaglobulin, and antimicrobial peptides.