Profiles include:
-- Tribal Leaders, such as Sitting Bull (Hunkpapa Lakota), Massasoit (Wampanoag), William Apess (mixed Pequot), and George Sword (Oglala Lakota)
-- Medicine Men and Women, such as Molly Ockett (Abenaki), Papounhan (Lenni Lenape), and Pretty Shield (Crow)
-- Warriors, such as Crazy Horse (Oglala-Brule Lakota), Kauxuma Nupika (Kootenai), and Stone Forehead (Northern Cheyenne)
-- Prophets, such as Neolin, the Delaware Prophet (Lenni Lenape), Wovoka (Northern Paiute), Nakaidoklini (Apache), Da'tekan (Kiowa), and Jake Hunt (Klickitat)
-- Scholars and Educators, such as William Jones (mixed Fox), Franz Boas, and Henry Rowe Schoolcraft
-- Traders, such as Magdelaine La Framboise (mixed Ottawa), Mary Musgrove (mixed Creek), and William Henry Ashley
-- American and European Statesmen, such as Patrick Henry, Andrew Jackson, and Lewis Cass
-- Guides and Army Scouts, such as Sacajawea (Shoshone), Francisco de Chicora (probably Shakori), Christopher "Kit" Carson, and Davy Crockett
-- Explorers, such as John Cabot, Jean Ribault, and William Clark
-- Artists and Photographers, such as Carl Bodmer and Howling Wolf (Southern Cheyenne).