A Southern Practice includes the diary that Hentz kept for more than twenty years, beginning with the river journey his family took from Ohio to Alabama when Charles was eighteen. This vividly depicted trip -- people, places, and sensory, details -- sets the stage for Hentz's record of his life through middle age: his apprenticeship and decision to pursue a medical career while a youth in Alabama; maturing as both a man and a doctor while at school in Kentucky; and establishing a general practice -- and a large family -- in the rough society of the Florida Panhandle. This edition also includes Hentz's autobiography, written at the end of his life, in which he reviews his past as doctor, southerner, and family man.

Taken together, Hentz's diary' and autobiography dramatize with unusual clarity and realism the demanding work of a physician in an age before medicine could reliably cure patients. The rural doctor's work plunged him into the center of his community's life. He attended patients enslaved and free; worked one day with the challenges of childbirth, another with desperately sick children; treated the victims of stabbings and shootings; and faced the looming threat of epidemic fever.

By telling what he liked to call his "professional stories", Hentz also gives a relatively rare picture of the feelings and experiences of a middle-class southern white man. His work, religious faith, and social relations with neighbors, slaves, and strangers are described. In their frankness,sharp observation, and good humor, Hentz's writings illuminate nineteenth-century, medicine in its full social setting, thus revealing a fresh portrait of the Old South.