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Amiloride-Sensitive Sodium Channels Physiology and Functional Diversity (volume47)

by Dale J. Benos

  • ISBN: 9780121533472
  • ISBN10: 0121533476

Amiloride-Sensitive Sodium Channels Physiology and Functional Diversity (volume47)

by Dale J. Benos

  • List Price: $220.00
  • Binding: Hardcover
  • Publisher: Academic Pr
  • Publish date: 05/01/1999
  • ISBN: 9780121533472
  • ISBN10: 0121533476
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Description: Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels and their regulation and involvement in normal and pathophysiological situations.
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