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Amiloride-Sensitive Sodium Channels Physiology and Functional Diversity

by Dale J. Benos

  • ISBN: 9780120890309
  • ISBN10: 0120890305

Amiloride-Sensitive Sodium Channels Physiology and Functional Diversity

by Dale J. Benos

  • Binding: Paperback
  • Publisher: Morgan Kaufmann Pub
  • Publish date: 02/01/1999
  • ISBN: 9780120890309
  • ISBN10: 0120890305
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Description: Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium-regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation, and their involvement in normal and pathophysiological situations.
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