Description: CHEMISTRY, OLD AND NEW. Oligonucleoside Methylphosphonates: Synthesis and Properties (P.Miller). Oligo(Nucleoside Phosphorothioate)s (P. Guga, et al.). Modified Oligodeoxynucleotides as Antisense Therapeutics (P.Seeberger & M. Caruthers). Novel Chemistry (K. Altmann, et al.). OLIGONUCLEOTIDE INTERNALIZATION, MECHANISM OF ACTION, ANDNON-SEQUENCE SPECIFICITY. Cellular Uptake and Biodistribution of Oligodeoxynucleotides (B.Hanss, et al.). Use of Cationic Lipid Complexes for Antisense OligonucleotideDelivery (C. Bennett). Nonantisense Effects of Antisense Oligonucleotides (L. Neckers& K. Iyer). Ribonuclease H-Mediated Antisense Effects of Oligonucleotides andControls for Antisense Experiments (D. Tidd). SEQUENCE-SPECIFIC INHIBITION OF GENE EXPRESSION. The Development of C-5 Propyne Oligonucleotides as Inhibitors ofGene Function (W. Flanagan & R. Wagner). The Use of Antisense Oligonucleotides to Inhibit Expression ofIsozymes of Protein Kinase C (N. Dean, et al.). BCR-ABL as a Target for Antisense Intervention (S. O'Brien & T.Smetsers). The NF-kB Transcription Factor (R. Narayanan). Disruption of the Map Kinase Signaling Pathway Using AntisenseOligonucleotide Inhibitors Targeted to RAS and RAF Kinase (B.Monia). Protein Kinase A-Directed Antisense Blockade of Cancer Growth:Single Gene-Based Therapeutic Approach (Y. Cho-Chung). Use of Antisense Oligonucleotides in the Central Nervous System:Why Such Success? (M. McCarthy). APPLIED ANTISENSE OLIGONUCLEOTIDE THERAPEUTICS. Perturbing Hematopoietic Cell Gene Expression withOligodeoxynucleotides: Research and Clinical Applications (A.Gewirtz & M. Ratajczak). BCL2 (B. Jansen & B. Brown). Biological Activity of Guanosine Quartet-Forming Oligonucleotides(R. Rando & M. Hogan). OLIGONUCLEOTIDES AS ANTI-HIV AGENTS. Perspectives on Antisense Technology Against HIV (J. Gee, etal.). In Vivo Pharmacokinetics of Oligonucleotides (S. Agrawal). Early Clinical Trails with Gem 91, A Systemic Oligodeoxynucleotide(R. Martin). THERAPEUTIC OLIGONUCLEOTIDE DATA BASE: PHARMACOKINETICS, IMMUNESTIMULATION, AND USE AS ANTIRESTENOTIC AGENTS. Antisense Therapy to Inhibit Angioplasty Restenosis (L. Rabbani& W. Wang). Pharmacokinetics of Oligonucleotides: A Review of Current Knowledgeand Issues for the Future (T. Wallace & P. Cossum). Leukocyte Stimulation by Oligodeoxynucleotides (A. Krieg). SELECTED OLIGODEOXYNUCLEOTIDE DEVELOPMENTAL TOPICS: SPLICING ANDTRIPLEXES. Modification of Alternative Splicing of Pre-mRNA by AntisenseOligonucleotides (R. Kole). Gene-Targeted Triple-Helix-Forming Oligonucleotides (F. Svinarchuk& C. Malvy). Triplex-Forming Oligonucleotides for Genetic Manipulation: AnAlternative View (A. Faruqi & P. Glazer). A REVIEW OF RIBOZYME TECHNOLOGY. Therapeutic Ribozymes: Principles, Applications, and Problems (J.Rossi). Index.

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