Description: This volume discusses the latest developments in research and clinical aspects of Charcot-Marie-Tooth disease (CMT), the most common peripheral neuropathy in humans, Recently there have been considerable advances in the understanding of CMT: the genetic causes of most of the demyelinating forms of CMT have been identified, and the molecular biology of peripheral nervous structure and the function of many of the molecules involved in the pathogenesis of CMT are becoming clearer. With the development of viral vectors to introduce genes into the peripheral nervous system, as well as trophic factors to promote nerve regeneration and remyelination, gene therapy for CMT is becoming a realistic possibility. These issues among others, are explored in this volume, and important areas of future research are discussed.

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