Description: PART I: Introduction1. Basic Concepts and the Functional Organization of the Immune SystemPART II: Phylogeny of the Immune System2. Development of Primitive Recognition Systems in Invertebrates3. Molecular Genetics of the Major Histocompatibility Complex4. Evolution of the Immunoglobulin Gene Superfamily5. Early Development of Immunoglobulins6. The Organization and Assembly of Immunoglobulin Genes7. Developmental Control of T Cell Antigen Receptor Gene Rearrangement and ExpressionPART III: Ontogeny of the Immune System8. Stem Cells9. Monocytes, Macrophages and Accessory Cells10. T Lymphocytes11. B Lymphocyte Generation as a Developmental ProcessPART IV: Molecular Aspects of Recognition and Regulation12. Antigen Processing and Presentation: Functional and Molecular Aspects13. Ontogeny and Function of Complement14. The Origin and Function of Cytokines Involved in the Development of Immune Responses15. T Cell Activation: Functional and Molecular Aspects16. Regulation of the B Cell Response: Activation and DifferentiationPART V: Development of the Immune System in Health and Disease17. The Thymosins: Immunological Manipulations and Pharmacology18. Immune Surveillance and Natural Immunity19. The Immunobiology of Aging20. Development of Normal and Abnormal Immune Function in Humans

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