Dickinson's illness compelled her to remain indoors with her eyes heavily bandaged for months at a time, especially during the summer. Guthrie maintains that these extended periods of sensory deprivation caused her to seek solace in writing and to convert her poems into replacements for her injured eyes. Many poems discuss her physical pain; many mention such topics as optics, astronomy, light, or the sun; some suggest that she blamed God for what had happened to her. These poems permitted her, Guthrie says, to use her personal experience as a spring board for discussing philosophical and religious matters and led her, finally, to conceive a system of metapoetics in which she served as translator or mediator between God's will and human experience.

Guthrie argues that reading the poems in an overtly biographical context deepens their complexity and profundity. Dickinson emerges from this study as an accomplished artist and an eminently sane and stable woman whose patience and optimism were sorely tested by severe, chronic illness.