Description: As our understanding of the structure and organization of the human genome grows, studies that can yield insight into genome function become increasingly important. Functional Analysis of the Human Genome reviews the range of techniques currently available for studying the relationship between structure and function, and assesses the strategies employed to ensure that each of these keeps pace with and complements the other. Topics covered include human genome mapping, cloning transcribed genes, retroviral insertional mutagenesis, gene trapping, gene transfer and expression, integration of foreign DNA and DNA methylation, use of transgenic animals in human gene analysis, homologous recombination and its applications (including gene therapy), and use of antisense oligonucleotides. Functional Analysis of the Human Genome is a timely and detailed account of this key area of study written by active researchers in the field. The aim has been to produce a book that is both authoritative and succeeds in provoking genuine excitement about this topic. Experienced researchers and newcomers to the subject alike will find this volume essential reading.

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