Description: Matrix metalloproteins are implicated in many physiological and pathological situations where the cell's extracellular matrix is turned over or degraded, so that they represent important therapeutic targets in a number of diseases including cancer. Matrix Metalloproteinase Inhibitors in Cancer Therapy covers the biology of MMP's through current clinical studies. In the first half of the book several authors discuss molecular mechanisms of the enzymes, substrates, natural inhibitors, and design strategy of MMP inhibitors. The remainder of the book is devoted to many of the individual pharmaceutical companies and their particular research on MMP inhibitors. Each company approaches this from design strategy, in vitro activity, animal model work, and, if available, toxicology and human clinical trial safety and efficacy.

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