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Molecular Toxicology

by P. David Josephy

  • ISBN: 9780195093407
  • ISBN10: 0195093402

Molecular Toxicology

by P. David Josephy

  • List Price: $94.95
  • Binding: Hardcover
  • Publisher: Oxford Univ Pr
  • Publish date: 08/01/1996
  • ISBN: 9780195093407
  • ISBN10: 0195093402
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Description: Molecular Toxicology reflects the revolution that toxicology has undergone in the last decade, as the molecular and genetic basis of the science - including drug metabolism, carcinogenesis, programmed cell death, and DNA repair - has been elucidated. It is the first text to explain the principles of toxicology in depth and from the perspective of modern biochemistry and molecular biology, while also providing a sense of the historical development of the science. Emphasizing the latest molecular biological approaches, the book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons, and chlorinated compounds. The toxicology of oxygen and oxidative stress is also covered in depth. Extensively referenced, up-to-date, and rigorous, Molecular Toxicology is an ideal textbook for advanced undergraduate and graduate courses in molecular and biochemical toxicology, and also serves as a valuable resource for instructors and practicing scientists.
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