Description: Internationally known researchers present in detail their best techniques for the extraction and isolation of natural products, particularly those that are unknown. These authoritative experimentalists demonstrate a wide array of methodologies, ranging from separations, chromatography and ion exchange to HPLC, countercurrent and planar chromatography, SFE, and crystallization. They also address the specific problems involved in working with plans, water-soluble compounds, dereplication and partial identification, and follow-up of a natural product lead. For the less experienced they offer hands-on advice -- using real examples -- about how to approach an extraction in general, when and why to apply a particular technique, how to carry out the methods described, and how to modify conditions to suit the nature of the compound being isolated.

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