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Practice of Medicinal Chemistry

by Wermuth, Camile G. E Wermuth

  • ISBN: 9780127446400
  • ISBN10: 0127446400

Practice of Medicinal Chemistry

by Wermuth, Camile G. E Wermuth

  • List Price: $206.95
  • Binding: Hardcover
  • Publisher: Academic Press
  • Publish date: 02/01/1996
  • ISBN: 9780127446400
  • ISBN10: 0127446400
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Description: This book collects in one single volume, the < I> practical aspects< /I> of Medicinal Chemistry, < I> seen from a chemical point of view< /I> , including the wealth of information which chemists accumulate over a career, but generally is never organized and presented in a coherent form in print. Emphasis is given to how medicinal chemists conduct their search for, and design of, new drug entities. In contrast to other books on the market, it focuses on the chemistry, rather than pharmacological concepts or description of the various therapeutic classes of drugs. It should become a standard reference on the tools available to medicinal chemists when designing new drugs. Key Features* These aspects are covered by: * Specific chapters devoted to the discovery of new lead compounds, including combinatorial chemistry* Clearly written chapters on modern topics such as stereochemical aspects of drug action, the use of X-ray structures of receptors and enzymes in drug discovery, and the contribution of molecular biology to drug discovery* Guidelines and operational strategems allowing identification of the portions of the molecule which are important for potency* The particular emphasis given to the three-dimensional aspects of the drug-receptor interactions, to the design of peptidomimetic drugs and to the control of the agonist-antagonist transition* Chemical solutions to solubility and to formulation problems These sections cover perhaps the most neglected areas in medicinal chemistry books* < I> Development of new drugs: legal and economic aspects< /I> , constitutes another important area in which chemists are almost wholly self taught following their entry intoindustry
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