The guide is divided into sections for each president. These sections include birthplaces, childhood homes, adult homes, schools attended, as well as the places where the presidents married, worked, worshiped, vacationed, retired, died, and were buried. Also included are presidential libraries, museums, major monuments, and a section that lists sites relevant to numerous presidents, such as the White House and Camp David. Each entry includes address, telephone number, hours, admission fees, and a short description of the site's role in that president's life. There is also a geographical index to show the locations that can be easily included in any travel itinerary.

One attractive feature of the book is a shaded box for each site that allows visitors to write the visitation date and any appropriate notes, thereby creating a personal travelogue. This feature also provides a place to use dated rubber stamps that resemble old-fashioned postage stamps, available for public use at all National Park Service sites.