Description: Thrombotic disease is a major cause of death and disablement in Western society. The most common cause is an inherited defect in one of the many genes encoding a protein which is involved in clotting, its regulation, or the process of clot dissolution, fibrinolysis. Venous Thrombosis: From Genes to Clinical Medicine presents our current knowledge of potentially prothrombotic protein abnormalities, together with a clear and concise view of the roles these proteins play in homeostasis, and the use of molecular techniques in the analysis and diagnosis of inherited defects. Each chapter describes a specific protein deficiency, with information on protein structure, function and biochemistry, gene structure and expression, as well as epidemiological and molecular genetic aspects of the deficiency state. This multifaceted approach aims to examine the possible causes of venous thrombosis, to explain the underlying molecular defects, and to explore the genotype-phenotype relationship in this complex multigene disorder. The potential roles of both epistatic interactions and environmental risk factors are also discussed Venous Thrombosis: From Genes to Clinical Medicine will be of value to hematologists, genetic counselors, and clinical geneticists.

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