Description: S.A. Schepartz: Introduction and Historical BackgroundK.D. Paull, E. Hamel, L. Malspeis: The Prediction of Biochemical Mechanism ofAction from the In Vitro Antitumor Screen of the National Cancer InstituteJ.A. Montgomery: Antimetabolites: IntroductionS. Ananthan: FluoropyrimidinesJ.A. Montgomery: ThiopurinesW.B. Parker: Inhibitors of Nucleoside Diphosphate ReductaseJ.A. Secrist, III: 2-Deoxyribonucleosides AnalogsJ.A. Montgomery: Other NucleosidesC.G. Temple, Jr.: Folic Acid AnalogsJ.R. Piper: Methotrexate and Related DiaminoheterocyclesJ.A. Montgomery: 6-Diazo-5-oxo-L-norleucine (DON)J.A. Montgomery: L-AsparaginaseJ.A. Montgomery: N-(Phosphonoacetyl)-L-aspartic Acid (PALA)J.A. Montgomery: Agents that React with DNA: IntroductionR.F. Struck: Nitrogen Mustard and Related StructuresR.C. Reynolds: AziridinesR.D. Elliott: NitrosoureasW.R. Waud: Platinum ComplexesY.F. Shealy: Triazenylimidazoles, Other Triazenes, and Imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-onesY.F. Shealy: Alkyl SulfonatesJ.A. Maddry: ProcarbazineJ.A. Maddry: HexamethylmelamineS.K. Sengupta: Topoisomerase II Inhibitors: Inhibitors of DNA TopoisomerasesW.A. Denny: The role of Intercalation and DNA Binding in the Activity ofAcridines and Related Tricyclic DNA - intercalating AgentsC.C. Cheng: Epipodophyllotoxins, Aminoanthraquinones, Ellipticine, Merbarone,Benzisoquinolinediones, and Related CompoundsS.K. Sengupta: Inhibitors of DNA Transcribing EnzymesM.E. Wall and M.C. Wani: Camptothecin and AnalogsM. Cory: DNA Minor-groove Binding CompoundsM.C. Lu: Antimitotic AgentsS.M. Hecht: Bleomycin Group Antitumor AgentsC.J. Kendrick-Parker and V.C. Jordan: AntihormonesT.J. Dougherty: Photochemically Activated Anticancer AgentsM. Awwad, H.R. Axelrod, and S.C. Gilman: Immune Modifying AgentsW.A. Denny: Hypoxia-Selective CytotoxinsB.. Teicher and E.A. Sotomayor: Chemical Radiation Sensitizers and ProtectorsA.R. Heider and T.J. Bardos: Oligo- and Polynucleotides as Potential CancerChemotherapeutic AgentsW.A. Remers and B.S Iyengar: Antitumor Antibiotics

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